Brand name:
Comtan
Pronounced: COM-tan
Generic name:
Entacapone
Why is Comtan prescribed?
Comtan is used for Parkinson's disease. It is prescribed when
doses of the combination drug levodopa/carbidopa (Sinemet) begin to
wear off too soon. By extending the effect of each dose of Sinemet,
it frees the patient from the stiffness and tremors of Parkinson's
for a longer period of time.
Comtan works by inhibiting the effect of an enzyme that breaks
down the levodopa in Sinemet. It has no effect on Parkinson's
disease when used by itself.
Most important fact about Comtan
Comtan's value lies in its ability to extend Sinemet's
effectiveness when it begins to decline. It is helpful only when
taken with the other drug, and has no benefit when used alone.
How should you take Comtan?
Comtan should be taken with each dose of Sinemet. It can be taken
up to 8 times per day, with or without food.
--If you miss a dose...
Take it along with a dose of Sinemet as soon as you remember. If
it is almost time for your next dose, skip the one you missed and go
back to your regular schedule. Never take 2 doses at the same time.
--Storage instructions...
Store at room temperature.
Comtan side effects
Side effects cannot be anticipated. If any develop or change in
intensity, inform your doctor as soon as possible. Only your doctor
can determine if it is safe for you to continue taking Comtan.
- Side effects may include:
Abdominal pain,
back pain,
constipation,
diarrhea,
discoloration of urine,
dizziness,
nausea,
onset of new movement disorders,
tired feeling,
vomiting
Why should Comtan not be prescribed?
If Comtan gives you an allergic reaction, you won't be able to
use it. It is prescribed only with caution for people with liver
disease.
Special warnings about Comtan
Use of Comtan can cause low blood pressure, with symptoms such as
dizziness, nausea, fainting, and sweating. Be careful when standing
up after you have been sitting or lying down. See how Comtan
affects you before you drive a car or operate machinery.
Nausea and diarrhea are especially common side effects of Comtan,
developing in more than 10 percent of those taking it. In rare
cases, the problem is severe. Comtan may also cause hallucinations,
and occasionally triggers new movement disorders. In about 10
percent of those taking it, it has the harmless side effect of
turning the urine a brownish-orange color.
An abrupt discontinuation of Comtan can cause a reappearance of
Parkinson's symptoms. If a decision is made to discontinue the drug,
it should be withdrawn slowly, under a doctor's supervision.
This drug is not intended for use in children.
Possible food and drug interactions when taking Comtan
If Comtan is taken with certain other drugs, the effects of
either could be increased, decreased, or altered. It is especially
important to check with your doctor before combining Comtan with the
following:
Antidepressant drugs classified as MAO inhibitors, including
Nardil and Parnate (Comtan can be used with a special type of MAO
inhibitor called selegiline, which is used for treating Parkinson's
disease)
Bitolterol (Tornalate)
Certain antibiotics, including ampicillin and erythromycin
Cholestyramine (Questran)
Methyldopa (Aldomet)
Isoproterenol (Isuprel)
Probenecid (Benemid)
Special information if you are pregnant or breastfeeding
The possibility of damage to a developing baby has not been ruled
out. Tell your physician immediately if you are pregnant or plan to
become pregnant. Comtan may appear in breast milk. It should be used
with caution if you are nursing your baby.
Recommended dosage for Comtan
ADULTS
Overdosage
Little is known about the result of Comtan overdose. However, the
results could be serious, so if you suspect an overdose, seek
medical attention immediately.
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